The following KEs that are so far not represented in the AOP-Wiki will enable AOP mapping of gene-environmentally induced NDDs such as microcephaly (ICD-11 classified LD20.2) caused by decreased NPC-proliferation KE (de Groot et al., 2005), ASD (ICD-11 6A02) linked to synaptic pruning KE (Pagani et al., 2021), as well as disorders linked to deficient autophagy KE (Deng et al., 2021). The gene discussed is NPC1; the disease is microcephaly.