Moreover, a wide range of AOPs including ACE2 are related to the SARS-CoV-2 virus (COVID-19) (https://www.ciao-covid.net/aops), which has been extensively studied in recent years (AOP IDs 379, 426, 430, 468), as the virus uses ACE2 as a cellular entry point for infection (Beyerstedt et al., 2021). Here, ACE2 is linked to infection.