These efflux transporters belonging to the family of ABC transporters such as P-glycoprotein (P-GP), multidrug resistance associated protein (MRP), breast cancer resistance protein (BCRP) inhibiting the penetration of numerous therapeutic drugs by actively pumping these substrates out of the cells (Agarwal et al., 2011) resulting in poor efficacy of commonly used antitumor drugs against glioma (Parrish et al., 2015). Here, ABCG2 is linked to central nervous system cancer.