Furthermore, B cells can secrete pro-angiogenic factors such as VEGF, CXC chemokine ligand 12 (CXCL12), and CXC chemokine ligand 13 (CXCL13), which stimulate the formation of new blood vessels, provide nutrients and oxygen to the tumor, and promote GB growth and invasion (Shonka et al., 2013). This evidence concerns the gene VEGFA and neoplasm.