Promoter methylation is known to play an epigenetic role in TMZ chemosensitivity by suppressing O6-methylguanine-DNA methyltransferase (MGMT) (Dunn et al., 2009).Pre-clinically, it was demonstrated that DNX-2401 infection decreased the IC50 of TMZ and MGMT levels in human GBM cell lines (U87 and T98G) in vitro (Alonso et al., 2007). Here, MGMT is linked to infection.