In summary, abnormal sphingolipid metabolism plays an important role in tumor metastasis and progression, and for tumor-associated pain, the S1P/S1PR1 axis seems to play a unique role in inducing neuropathic pain mainly by affecting astrocytes to mediate glial cell-neuron interactions that drive neuroinflammation and sensitization both centrally and peripherally. The gene discussed is S1PR1; the disease is neoplasm.