Rs2980976 is located on TNFRSF1A (Ensembl, 2024), coding for a protein belonging to the family of TNF-alfa receptors, expressed in the brain and playing a role in the pathway of NFkB (Yue et al., 2009), a protein involved in immune response, neuroinflammation being an established feature of many mental disorders, including schizophrenia and bipolar disorder (Leucht et al., 2007). Here, NFKB1 is linked to bipolar disorder.