Rs2980976 is located on TNFRSF1A (Ensembl, 2024), coding for a protein belonging to the family of TNF-alfa receptors, expressed in the brain and playing a role in the pathway of NFkB (Yue et al., 2009), a protein involved in immune response, neuroinflammation being an established feature of many mental disorders, including schizophrenia and bipolar disorder (Leucht et al., 2007). This evidence concerns the gene TNFRSF1A and bipolar disorder.