ALOX15 and kidney disorder: ALOX15 and its metabolites have also been implicated in the pathology and mechanism of T2DM, which may be related to the effect of ALOX15 on islet cell and macrophage functions, (He et al., 2023), as well as in serious complications that arise from the disease, such as diabetic retinopathy, peripheral neuropathy, and nephropathy (Singh and Rao, 2019).