In a study led by Zhuo and colleagues, FAA significantly downregulated the expression of both AKR1C1 and AKR1C3 in murine metastatic breast tumor cells (4T1/luc) and human HCC cells (HepG2), indicating a lack of selectivity over AKR1C1 (Li et al., 2020). This evidence concerns the gene AKR1C1 and hepatocellular carcinoma.