This interaction between AKR1C3 and ARID3A was associated with decreased chemosensitivity to 5-fluorouracil (5-FU) in colon cancer cells, suggesting that the ARID3A to AKR1C3 ratio may serve as a valuable marker for predicting the prognosis of colon cancer patients (Li et al., 2022). This evidence concerns the gene ARID3A and malignant colon neoplasm.