AKR1C3 has been demonstrated to facilitate PCa cells angiogenesis and aggressiveness through upregulating the expression level of insulin-like growth factor (IGF)-1, Akt, and vascular endothelial growth factor (VEGF) from bioinformatics analysis and functional genomics (Dozmorov et al., 2010). The gene discussed is VEGFA; the disease is posterior cortical atrophy.