Targeting AKR1C3 using aptamer-PSMA guided siAKR1C3@PPA that is assembled from PEG3500, PAMAM, and siRNA for AKR1C3 into PSMA-positive PCa cells, resulting in specific downregulation of AKR1C3 and potential cell cycle arrest (Cui et al., 2022). This evidence concerns the gene FOLH1 and posterior cortical atrophy.