Emodin treatment improved urinary albumin, serum creatinine, and blood urea nitrogen levels in DN mice and attenuated foot cell apoptosis by inhibiting the PERK-eIF2α signaling pathway in vitro and in vivo, suggesting a possible therapeutic role for emodin in DN (Tian et al., 2018). Here, EIF2AK3 is linked to liver dysplastic nodule.