Additionally, sEH inhibition increased kidney levels of the NF-κB inhibitor IκB in the HFD mouse model of DN, resulting in decreased mRNA expression of the kidney inflammatory markers COX-2, vascular cell adhesion molecule-1 protein and monocyte chemoattractant protein-1 (Roche et al., 2015). This evidence concerns the gene VCAM1 and liver dysplastic nodule.