ALOX12 and liver dysplastic nodule: In rats with STZ-induced DN, podocyte-specific mRNA levels, as well as fibronectin and collagen a5(IV) protein levels, are increased, which correlate with increased 12-LOX mRNA and protein expression, increased p38 mitogen-activated protein kinase (MAPK) mRNA expression, and p38 MAPK protein activation (Ma et al., 2005; Watanabe et al., 2018).