However, TGF-β has a disruptive effect on glomerular filtration, leading to glomerular damage in the early stage of DN and directly increasing the permeability of the glomerulus to albumin (Palb), which is associated with a decrease in 20-HETE formation (Sharma et al., 2000; Schiffer et al., 2001; Luo et al., 2009). Here, TGFB1 is linked to liver dysplastic nodule.