For example, it was reported that abrogated circular RNA circNOLC1 expression by propofol/STAT3 attenuates breast cancer stem cell function through miR-365a-3p/STAT3 signaling [41]; Local anesthetics was also reported to impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation [42]. This evidence concerns the gene STAT3 and breast carcinoma.