PSEN1 and familial Alzheimer disease: Herein, we have studied the featuresof Aβ deposits in braintissue sections from individuals with sAD or fAD associated with the PSEN1 A431E mutation by applying a novel combination stainingprotocol based on the new generation of thiophene-based ligands, anAβ-selective ligand, HS-276,37 anda D-A-D ligand, LL-1.39 The choice of ligandswas mainly based on two previous observations.