They are found most frequentlyin cases of genetically determined AD in association with a subsetof presenilin-1 (PSEN1) mutations.26−28 Since CWPsare abundant in association with this subset of genetically determinedAD, decreased binding of PiB to CWPs results in an underestimationof the load of Aβ deposits.26 Here, PSEN1 is linked to Alzheimer disease.