TLRs are crucial for the anti-tumor functions of DCs.374 DC maturation depends on the TLR signaling pathway, and activation of TLR4 or TLR7/8 can induce DC maturation.375,376 The loss of the TLR adapter molecule MyD88 results in poor DC maturation, characterized by significantly reduced proliferation and survival capabilities of antigen-specific naive CD4+ T cells. The gene discussed is TLR4; the disease is neoplasm.