For example, the enhancement of STING pathway ubiquitination degradation mediated by Galectin-9 in tumor cells can promote the expression of IL-1β and IL-6, thereby promoting the expansion of MDSCs.261 In GBM, under the influence of TME, the binding between PP2Ac and MST1/2 in TAMs cannot be dissociated by cGAMP. This evidence concerns the gene LGALS9 and glioblastoma.