Non-POU domain-containing octamer-binding protein (NONO) is a multifunctional nuclear protein capable of binding to DNA, RNA, and proteins.534 Previous research has shown that NONO can retain cGAS in the cell nucleus and, during HIV infection, promotes cGAS’s DNA sensing by detecting and binding the nuclear viral capsid, thus facilitating the activation of innate immunity mediated by cGAS.535 The role of NONO as a nuclear sensor in cancer has been less explored. This evidence concerns the gene NONO and cancer.