TNF and neoplasm: In chronic lymphocytic leukemia, IL-6 elevates miR-17 and miR-19a, targeting TLR7 and TNFA mRNA, inducing tumor cell tolerance to TLR7 agonists.415 In patients with colorectal carcinoma, downregulation of miR-143 has been observed, which facilitates the upregulation of TLR2 expression, thereby promoting tumor cell migration.416 Interestingly, metabolism also plays a role in regulating TLR expression.