By applying, decitabine, a DNA methyltransferase inhibitor, STING expression can be restored, thus reinvigorating STING’s responsiveness to its agonist, cGAMP.256,257 In a separate study, the combination of zebularine (a demethylating agent) and the STING agonist cGAMP effectively induced ISG expression and augmented the infiltration of CD8 T cells and NK cells into tumors, consequently inhibiting tumor growth and prolonging mouse survival. Here, CD8A is linked to neoplasm.