NLRP3 and gastric cancer: In gastric cancer, for example, NLRP3-mediated IL-1β has been shown to promote tumorigenesis.436 Conversely, in lymphomas, NLRP3-mediated IL-18 promotes lymphoma cell proliferation and inhibits apoptosis by upregulating c-MYC and BCL-2 expression, while downregulating TP53 and BAX expression.437