Moreover, Gene Ontology analysis indicates a “positive regulation of vasculature development.” Concurrently, microglia display a transcriptomic phenotype resembling that of age-related microglia.52 Specific microglial clusters also exhibit enhanced anti-inflammatory CXCL10 secretion and enriched expression of T-cell inhibitory molecules such as VISTA and PDL1.55 In addition, microglia in the glioma environment show impaired type I IFN signaling and NF-κB signaling.56 These findings all indicate the impairment of the anti-tumor immune function of microglia in the glioma environment. Here, VSIR is linked to central nervous system cancer.