For instance, STING is essential in inducing an IFN-dependent T cell anti-tumor response,238 while TLRs are necessary for the maturation of DCs.371,372 Additionally, the effectiveness of ICBs depends on the sufficient expression of corresponding receptors on target cells, and innate immune pathway agonists can upregulate the expression of these molecules.218,220,499,524. This evidence concerns the gene STING1 and neoplasm.