JMJD4 and hepatocellular carcinoma: A diminished expression of RIG-I promotes the onset of HCC.487,488 During HCC onset, the demethylase JMJD4 acts on RIG-I, inhibiting necrotic inflammation and the subsequent onset of liver cancer induced by nonalcoholic steatohepatitis.487 Furthermore, RLR activation can suppress tumor development through multiple pathways.