NANOG and colonic neoplasm: JMJD2B causes demethylation at the promoter of core stemness transcription factors Nanog homeobox (NANOG), thereby promoting the expression of NANOG, which enhances tumor stemness.283 Additionally, in colon cancer cells, TLR4 mediates immunosuppressive Siglec-7 ligands’ promoter methylation through the NF-κB pathway, leading to epigenetic silencing of its expression.284