These transformed fibroblasts activate WNT5A expression through the IFNAR/STAT1 pathway, which in turn promotes β-Catenin expression in tumor cells, enhancing tumor stemness and leading to poor patient prognosis.222 The pro-tumoral role of fibroblasts in bladder cancer suggests that the downstream pathways mediated by the cGAS-STING pathway are cell-type-specific. Here, CGAS is linked to neoplasm.