Limited studies suggest that in proliferating cells, the interaction between SAFA and the lncRNA PANDA can inhibit the transcription of pro-senescent genes, thus maintaining the cells in their current proliferative state.520 In Esophageal Squamous Cell Carcinoma, SAFA is significantly more expressed in tumor tissues compared to normal tissues. This evidence concerns the gene HNRNPU and esophageal squamous cell carcinoma.