ZBP1 and cancer: It detects viral-generated Z-form dsRNA (Z-RNA) and mediates RIPK3-dependent apoptosis and MLKL-dependent necroptosis.515 The mediation of necroptosis by ZBP1 suggests a potential role in cancer therapy, as nuclear necroptosis is significantly more immunogenic than cytoplasm-induced necroptosis due to the release of numerous DAMPs such as HMGB-1, IL-33, and DNA itself.515