STAT1 and neoplasm: The hypoxic environment in tumors induces HIF-1α, which downregulates the expression of RIG-I.508 In melanoma’s tumor-repopulating cells, a highly tumorigenic subpopulation with self-renewing capabilities, the activation of integrin β3/c-SRC/STAT3 pathway suppresses RIG-I, subsequently affecting STAT1 activation and resulting in resistance to apoptosis induced by IFN-α.511