CD274 and neoplasm: Hypoxic TME upregulates the HIF1α pathway, promoting PD-L1 expression in TANs.70 In glucose-deprived TME, TANs show higher GLUT1 expression, glucose uptake, and glycolysis.95 Enhanced glycolysis promotes the formation of neutrophil extracellular traps (NETs) which are decondensed chromatin combined with content from their azurophilic granules extruded by TANs.96 NETs can bolster tumor growth.