The activation of TLRs/Myd88/TRAF6 can induce SIRT2 (Sirtuin 2) to undergo autophagosome translocation, leading to its release into the ECM where SIRT2 promotes cancer cell metastasis, presumably by deacetylating multiple extracellular proteins, including ITGB3 (Integrin Subunit Beta 3) and collagens.373. Here, SIRT2 is linked to cancer.