Hypoxia induces TAMs to upregulate the expression of SLC40A1 (solute carrier family 40 member 1) and lipocalin 2, which promotes the supply of iron to tumor cells, consequently facilitating tumor proliferation.24,25 Hypoxia also influences TAMs’ glucose metabolism, contributing to tumor growth, although the specific mechanisms remain unclear. Here, SLC40A1 is linked to neoplasm.