CGAS and neoplasm: Tumor cells can evade immune phagocytosis by expressing CD47.239,240 Blocking CD47 can inhibit tumor growth, and multiple studies have shown that the tumor-suppressing effect of CD47 blockade therapy depends on the inherent STING pathway in DC cells.241–243 After blocking CD47, DCs, rather than macrophages, preferentially ingest mitochondrial DNA derived from tumors, activating the cGAS-STING pathway, promoting type I IFN production and cross-priming, leading to the activation of CD8+ T cells.241