NOD1 and neoplasm: In vitro and in vivo experiments have demonstrated that the knockdown of NLRP3 in tumor cells not only inhibits cellular proliferation but also suppresses the migratory capabilities of these cells partially through the upregulation of EMT-related gene.456 Additionally, in metastatic cervical squamous cell carcinoma cells, the upregulation of NOD1 and NOD2 expression promotes proliferation, invasion, and migration.