CGAS and neoplasm: Additionally, in cervical cancer, the human papillomavirus (HPV), a key causative agent, produces oncoproteins E1A and E7 that bind to STING, inhibiting its functionality, thereby undermining host immunity and facilitating tumorigenesis.264 Beyond directly affecting STING, mutations within the tumor can also interfere with other proteins in the cGAS-STING pathway.