TBK1 and neoplasm: Downstream products of bone marrow cell TLRs, such as IL-1β and IL-23, can induce activation and proliferation of γδ T cells, mediating chronic inflammation and thus promoting lung cancer development.587 Another study based on an intraperitoneal colorectal cancer and melanoma transplant tumor model in mice showed that oral administration of Lactobacillus rhamnosus GG (LGG) could promote IFN-β production by inducing the DCs’ cGAS/STING/TBK1/IRF7 axis.