For instance, while TLR2 in microglia enhances CD8+ T cell infiltration and activation, thereby inhibiting glioma via the TLR2-MHC-I axis,648 its activation in glioma cells bolsters tumor development by augmenting autophagy.649 Additionally, the expression and levels of TLRs differ across cell types. Here, TLR2 is linked to central nervous system cancer.