This process facilitates the effective phagocytosis of apoptotic tumor material by APCs, especially DCs, and subsequent activation via cross-presentation to prime CD8+ T cells.490,492 Importantly, intrinsic RIG-I signaling and caspase-3-mediated programmed tumor cell death are essential for the success of anti-CTLA-4 immunotherapy.490. The gene discussed is CTLA4; the disease is neoplasm.