High expression of ALKBH5 can inhibit the m6A modification of DDX58 mRNA, impair its maturation, and cause damage to the RIG-I/IFNα axis, resulting in immunosuppression, including a reduction in the number of tumor-infiltrating lymphocytes.512 Additionally, a suggestive study showed that the knockout of MEX3A, a protein that binds and ubiquitylates RIG-I, can increase the content of RIG-I protein in GBM and is related to tumor growth inhibition.513 miRNA also plays a role in regulating RLRs and influencing tumor prognosis. This evidence concerns the gene IFNA1 and glioblastoma.