Studies indicate that cGAS-STING can promote metastasis through the activation of non-canonical NF-κB pathways in a tumor cell-autonomous manner.13 Contrary to this, research on colon cancer revealed that CIN could promote metastasis in a cGAS/STING-independent fashion, and silencing cGAS/STING had no impact on tumor invasiveness.227 Therefore, the role of cGAS-STING in the metastasis of tumors may be tumor-type- or CIN-type-specific, necessitating further in-depth studies to clarify the role of the cGAS-STING pathway in tumor metastasis. The gene discussed is NFKB1; the disease is malignant colon neoplasm.