STING1 and neoplasm: The specific knockout of endogenous STING in B cells through CD19Cre; STINGflox/flox mice increased the numbers of antigen-specific plasma cells and antibody levels.250 In the PDAC model, it was also found that the activation of intrinsic STING in B cells can increase the frequency of IL-35+ and IL-10+ Breg cells, thereby reducing the frequency of NK cells and impairing anti-tumor immunity.