Activation of TLR4 not only induces DC maturation but also promotes the proliferation of CD8+ T cells mediated by DCs.378 Besides, TLR4 can upregulate the expression of co-stimulatory molecules and inhibit phagolysosome fusion of DCs, thereby enhancing cross-presentation and promoting the priming of CD8+ T cells.376 In addition to influencing DC-T cell interactions, TLRs also impact the anti-tumor immunity of NK cells. This evidence concerns the gene CD8A and neoplasm.