This regulation promotes the proliferation and malignant transformation of these cells.287 In addition, the activation of TLRs can influence the levels of miRNAs, which, in turn, can affect the transmission of TLR signals, targeting proteins and transcription factors along the pathway.288 In pancreatic cancer in vitro experiments, it has been discovered that the activation of TLR4 decreases the level of miR-29C through the NF-κB pathway. This evidence concerns the gene TLR4 and familial pancreatic carcinoma.