TNF and neoplasm: For example, blocking these inducing factors, such as TGF-β or glutaminase, has been found to reverse the suppressive state of TANs.105,106 Besides, type I IFNs can promote N1 polarization in TANs, inhibiting tumor metastasis.108,109 Recent research has revealed that combining tumor necrosis factor (TNF), a CD40 agonist, and a tumor-binding antibody can activate neutrophils to kill tumor cells through a complement-mediated oxidative mechanism.