CIITA and neoplasm: The NAIP family member CIITA and the NLRC family member NLRC5 (CITA) can respond to IFN-γ, mediating the expression of MHC II and MHC I molecules, respectively.422,423 Given the essential role of MHC I and MHC II in the immune response, interfering with CIITA and NLRC5 may have positive effects on anti-tumor immunity.