The TNFα released by the activation of STING in tumor-associated myeloid cells can stimulate the TNFα-TNFR1 pathway in endothelial cells, leading to apoptosis of these cells and thus leading to the destruction of the tumor blood vessels.211 The use of STING golden-ticket (point mutation of STING) mice and wild-type mice bone marrow chimeras demonstrates that chimeric tumor-bearing mice formed from Sting golden-ticket-origin bone marrow and wild-type mice nearly lose their ability to respond to STING-mediated cytokines, such as IFNγ. The gene discussed is TNF; the disease is neoplasm.