Conversely, another study demonstrated that IL-18 secretion mediated by NLRP3 in hepatic macrophages inhibits liver metastasis of colorectal cancer by promoting the maturation and function of NK cells.459 These conflicting viewpoints might be reconciled by considering different contexts: the former emphasizes the pro-metastatic role of NLRP3 in primary tumors, whereas the latter underscores its anti-tumor effects at metastatic sites. Here, IL18 is linked to colorectal cancer.