For example, increased RIG-I expression in T cells suppresses T-cell survival and anti-tumor cytotoxicity.504 Increased expression of RIG-I in PDAC promotes tumor growth and is associated with a poor prognosis in patients.505 LGP2, upon stimulation by radiotherapy-induced IFNβ during radiotherapy, can be overexpressed. This evidence concerns the gene IFNB1 and neoplasm.