TNFSF10 and neoplasm: One such method is irreversible electroporation, a treatment that involves introducing electrodes into tumors to deliver electric pulses, prompting tumor cell apoptosis.602,603 Another approach is the use of apoptosis-inducing agents, such as combining TRAIL receptor agonists—which induce apoptosis—with sensitizers of the TRAIL-induced apoptotic pathway, like bortezomib, a proteasome inhibitor.604 These combined strategies have demonstrated superior efficacy compared to monotherapies that solely utilize innate immune activators.602–604