HIF1A and central nervous system cancer: In these two clusters, the expression of CX3CR1 and SELPLG (CD162) in microglia is significantly downregulated.49,52 CX3CR1 and SELPLG act as the glioma sensors that promote microglial infiltration into the tumor.53,54 In addition, compared to healthy controls, cluster data from the glioma group revealed higher expression of hypoxia-related genes such as hypoxia-inducible factor 1α (HIF-1α) and VEGF α.52