For example, aberrantly amplified proteins such as HER2 can recruit and bind to AKT1, inhibiting the regular binding of TBK1-STING and thereby weakening STING-mediated signaling to suppress anti-tumor immunity.260 The tumor cell-intrinsic cGAS-STING pathway also has negative regulation of anti-tumor cells. The gene discussed is CGAS; the disease is neoplasm.