This transition serves as the initial step in tumor dissemination.344 Activation of TLR7 in tumor cells also mediates the infiltration of MDSCs thus promoting the expression of genes related to invasion and metastasis, such as ICAM-1 (intercellular adhesion molecule 1), cytokeratins 7 and 19, thereby enhancing EMT.345. The gene discussed is TLR7; the disease is neoplasm.