CD47 and central nervous system cancer: Moreover, the APC’s processing of tumors can release DAMPs, stimulating the activation of endogenous innate immune pathways.606 Furthermore, the enhancement of APC phagocytic activity can also increase the uptake of exogenously provided agonists, amplifying their effective dose.607 However, tumor cells have developed mechanisms to evade phagocytosis, notably by upregulating the anti-phagocytic molecule CD47.608 Based on this, researchers have crafted a blood-brain barrier-permeable nanocapsule to deliver both anti-CD47 antibodies and STING agonists directly to gliomas.