Radiochemotherapy stands as the most clinically prevalent method for stimulating DAMP production.594–596 Additionally, radiochemotherapy facilitates the release of tumor antigens, thus promoting the antigen presenting of APCs.594 In murine models of pulmonary metastasis stemming from melanoma and breast cancer, the combined application of STING and chemotherapy markedly amplified the anti-cancer effects of STING. The gene discussed is STING1; the disease is melanoma.