It has been found that lung stromal cells can transport lipids to NK cells via exosome-like vesicles, causing lipid accumulation in NK cells.117 In lipid-rich environments, accumulated lipids induce NK cells to inhibit the mTORC1 pathway through upregulation of the PPAR pathway.118 The inhibition of mTOR, which is thought to be the central metabolic regulator promoting glycolysis, reduces the glycolytic capacity of NK cells.118,119 Tumor cells also transmit inhibitory signals through direct cell contact. The gene discussed is MTOR; the disease is neoplasm.