CD8A and neoplasm: After STING activation, the autocrine type I IFNs reeducate MDSCs into an anti-tumor phenotype that acquires the ability to activate CD8+ T cells.248 It is important to note that in MDSCs, the PKR-like endoplasmic reticulum (ER) kinase (PERK) can inhibit the activation of the cGAS-STING pathway.248 Therefore, when targeting the cGAS-STING pathway in MDSCs for therapeutic purposes, attention must be paid to this aberrant suppression within the pathway.