For instance, the NLRP1 inflammasome-modulated secretion of IL-1β and IL-18 by non-hematopoietic derived cells, likely intestinal epithelial cells, help to maintain the integrity of the epithelial barrier in the colon, thus suppressing tumor formation in inflammation-related mouse colon carcinogenesis models.433,434 Besides, IL-18 promotes the secretion of IFN-γ, which subsequently activates the STAT1 pathway in tumor cells to exert a tumor-suppressive effect.435. This evidence concerns the gene IL18 and neoplasm.