This metabolic shift from Warburg respiration (high glycolytic metabolism) to mitochondrial respiration reduces glucose uptake, increasing relative glucose availability for tumor cells and endothelial cells.26 On the other hand, some studies have found that hypoxia increases glucose transporter 1 (GLUT1) expression in TAMs, enhancing glucose uptake and glycolysis. Here, SLC2A1 is linked to neoplasm.