Golgi membranes containing STING can serve as a membrane source for autophagosome biogenesis, and cGAMP stimulation promotes lipidation of the key autophagy biogenesis factor, LC3.180 Notably, the STING-autophagy pathway can drive an autophagic cell death program during the cellular replicative crisis, serving as a preventative mechanism against the formation of tumor cells (Fig. 3).188. The gene discussed is STING1; the disease is neoplasm.