The specific knockout of STING in cDCs using zbtb46Cre; STINGflox/flox mice revealed that intrinsic STING in cDCs is necessary for the Th1 CD4+ T (IFN-γ+ CD4+ T) cell response induced by DNA vaccines and also for Th1 type IgG2C antibody response.237 Moreover, DCs rely on their inherent STING pathway to effectively initiate IFN-dependent T-cell responses to tumor antigens.238 Research has shown that the inherent STING pathway in DC cells is indispensable for the activation of T cells by intracranial injection of virus-like particles delivering cGAMP.208. Here, CD4 is linked to neoplasm.