For instance, while TLR2 in microglia enhances CD8+ T cell infiltration and activation, thereby inhibiting glioma via the TLR2-MHC-I axis,648 its activation in glioma cells bolsters tumor development by augmenting autophagy.649 Additionally, the expression and levels of TLRs differ across cell types. The gene discussed is CD8A; the disease is glioma.