Compared to the specific activation of STAT1 by the high concentration of type I IFN, the low concentration of type I IFN simultaneously activates STAT3.219 The reasons behind this pathway transformation are unclear, but it may be related to the plasticity changes in the STING pathway due to CIN-induced chronic activation. The gene discussed is STING1; the disease is cervical squamous intraepithelial neoplasia.