For instance, TLR7/8 agonists stimulate dendritic cell activation and the production of type I IFNs and other pro-inflammatory cytokines, thereby initiating T-cell cytotoxicity and enhancing tumor immunogenicity, which inhibits TNBC metastasis.351 Activation of anti-tumor cell TLRs has also demonstrated anti-metastatic effects. The gene discussed is TLR7; the disease is neoplasm.