In NSCLC, neutrophil extracellular traps downregulate the expression of lncRNA MIR503HG, activating the NF-κB/NLRP3 pathway to promote EMT and NSCLC metastasis.480 Tumor cells deliver exosomal miR-21 that represses macrophage PTEN and BRCC3, facilitating NLRP3 phosphorylation and lysine-63 ubiquitination, thus inhibiting NLRP3 inflammasome assembly. The gene discussed is NLRP3; the disease is neoplasm.