CGAS and glioblastoma: YAP then acts as an inhibitor of TBK1 and IRF3, which are downstream of the STING pathway, thereby inhibiting IFN production.262 Furthermore, it has also been observed that the high expression of PCBP2 (Poly(rC) Binding Protein 2) in GBM is able to inhibit the cGAS-STING pathway by binding to cGAS.263