A diminished expression of RIG-I promotes the onset of HCC.487,488 During HCC onset, the demethylase JMJD4 acts on RIG-I, inhibiting necrotic inflammation and the subsequent onset of liver cancer induced by nonalcoholic steatohepatitis.487 Furthermore, RLR activation can suppress tumor development through multiple pathways. Here, RIGI is linked to liver cancer.