Tumor cells and their supporting cells compete for glucose, leading to a relative deficiency in glucose uptake by CTLs.132 CTLs also downregulate the activity of enolase 1, a critical enzyme in the glycolytic pathway, impairing glycolysis and thus diminishing their anti-tumor functionality.133 Additionally, the hypoxic environment of tumors induces the accumulation of lactate. Here, ENO1 is linked to neoplasm.