EDN1 and endothelial dysfunction: Arterial stiffness and endothelial dysfunction, important mechanisms for vascular diseases, correlate with kidney dysfunction and albuminuria.99, –101 SGLT2 inhibitors have been shown in clinical trials to modestly lower pulse wave velocity, a measure of arterial stiffness, and improve brachial artery flow mediated dilation, a measure of endothelial dysfunction.94, –96 In addition, there may be a connection between SGLT2 inhibitors and endothelin-1, a potent vasoconstrictor.