HDAC1 and early-onset autosomal dominant Alzheimer disease: Given that deletion of HDAC1/2 has been shown to reduce neuroinflammation mediated by microglia and improve neurological conditions in Alzheimer's disease mouse models,28 our initial step was to determine if inhibiting HDAC1/2 could similarly influence microglial heterogeneity and neuroinflammation in an in vitro model of ICH.