TIF1γ is a 155 kDa nuclear protein discovered by Targoff et al. by immunoprecipitation,11 and most cohort research indicated that anti-TIF1γ is highly associated with an increased risk of malignancy in myositis.12, 13, 14 In this cohort study, anti-TIF1γ was considered more common in mild DM (cluster 3). The gene discussed is TRIM33; the disease is dermatomyositis.