IQCB1 and Leber congenital amaurosis: The IQCB1 gene (IQ calmodulin-binding motif-containing protein-1; also known as NPHP5) is located on chromosome 3q13.33, with pathologic variants associated with Senior-Loken syndrome (SLS), a rare autosomal recessive condition involving renal dysfunction and LCA/EOSRD.