Similar to our observations in mouse leukemia cells, inducible expression of FADS1-targeting shRNAs (i-shFADS1.1 or i-shFADS1.2) impeded the growth of human AML cell lines expressing MLL-AF9 (NOMO1 and MOLM14) as well as that of a normal-karyotype AMLcell line, OCI-AML3 (Figs. 2, F and G, and S1, F–I). The gene discussed is KMT2A; the disease is leukemia.