In two other AML patient cohorts (20, 21), we found that FADS1 mRNA is elevated across multiple AML subtypes compared to healthy controls and is particularly high in mixed lineage leuekmia (MLL) (also known as KMT2A)-rearranged leukemia (Fig. 1, C and D). The gene discussed is KMT2A; the disease is acute myeloid leukemia.