The univariate analysis of the other parameters examined showed that there was a progressive decline in both OS and DFS with advanced T stage (OS, p < 0.0001 and, DFS, p = 0.004) presence of distant metastasis (OS, p < 0.0001 and DFS, p < 0.0001), presence of higher tumor budding (OS, p < 0.0001 and DFS, p = 0.005), and with presence of KRAS mutations (OS, p = 0.002 and DFS, p < 0.0001) (Figs. 3, 4). This evidence concerns the gene KRAS and neoplasm.