While the cornerstone for TLS formation in epithelial cancers is TFH cells,25, 47 both B lymphocytes and TFH cells get accumulated in the tumor microenvironment by a common chemokine, CXCL1348 because both cell types express CXCR5,49 the only known receptor of CXCL13.50, 51, 52, 53. The gene discussed is CXCR5; the disease is neoplasm.