MDSCs96 in the tumor microenvironment force B cell differentiation into IL‐10, IL‐35, and TGF‐β‐producing97 immunosuppressive regulatory B cells (Bregs),98, 99 however, Bregs do not have any unique identification marker like FOXP3 for Tregs, and therefore the classification of Bregs among total B cells is elusive. The gene discussed is TGFB1; the disease is neoplasm.