However, binding of dimeric IgA antibodies with PIGR, which is quasi‐universally expressed by virtually all epithelial cancers, elicits transcytosis of dimeric IgA that upregulates DUSP phosphatases, which, in turn, dephosphorylates ERK1/2 and thereby dampens RAS pathway, and also sensitizes the cancer cells for MHC‐independent killing by cytotoxic T cells.13, 76. This evidence concerns the gene PIGR and cancer.