Hypermethylation of the DAPK, MGMT, MSP tumor suppressor gene (also known as CDKN2A or INK4a), Hypermethylation of the Death‐Associated Protein Kinase (DAPK) gene, methylation of the O‐6‐methylguanine‐DNA methyltransferase (MGMT) gene, hypermethylation of the RAS association domain family 1A (RASSF1A) gene promoter region is well‐documented in various cancers, including HNSCC.38, 39, 40, 41. Here, CDKN2A is linked to head and neck squamous cell carcinoma.