Hypermethylation of the DAPK, MGMT, MSP tumor suppressor gene (also known as CDKN2A or INK4a), Hypermethylation of the Death‐Associated Protein Kinase (DAPK) gene, methylation of the O‐6‐methylguanine‐DNA methyltransferase (MGMT) gene, hypermethylation of the RAS association domain family 1A (RASSF1A) gene promoter region is well‐documented in various cancers, including HNSCC.38, 39, 40, 41. The gene discussed is RASSF1; the disease is head and neck squamous cell carcinoma.