Aurora kinases are serine/threonine protein kinases that are part of the CPC (Chromosome Passenger Complex) and play a key role in chromosome segregation during mitosis.25 Due to their role controlling cell division, Aurora kinases (AURKs) are often overexpressed or amplified in human cancers, including PTC and ATC.26 AURKs have also been shown to promote progression of thyroid cancer.27 Thus, we hypothesized that inhibition of AURKB would sensitize cells to MAPK-directed therapies. The gene discussed is AURKB; the disease is thyroid gland carcinoma.