ANGPT2 and endothelial dysfunction: Importantly, Ang-2 has been identified as a prognostic biomarker in sepsis [87, 88], with Ang 2 levels correlating with disease severity and survival [89].The prominent role of the angiopoietin-Tie 2 pathway in endothelial dysfunction makes modulation of the Ang-1/Ang-2/Tie-2 equilibrium an attractive therapeutic target in sepsis.