The estimated associations with MG per 1 SD increase in the genetically predicted circulating CTSH level were consistent between the INTERVAL (OR = 1.257; 95% CI 1.125–1.405; P = 5.49 × 10–4) and ARIC (OR = 1.218; 95% CI 1.101–1.348; P = 1.330 × 10–4) studies and displayed strong evidence of colocalization (Fig. 5). This evidence concerns the gene CTSH and myasthenia gravis.