In human hepatocellular carcinoma cells treated with TGF-β1 induction, reduced expression of the GnTIII gene and its catalytic product bisected GlcNAc structure, led to the up-regulation of Smad3 and Erk1/2 phosphorylation, which ultimately led to the EMT process of hepatocellular carcinoma [34]. The gene discussed is SMAD3; the disease is hepatocellular carcinoma.