The difference in CME rates was primarily due to significantly higher rates of ADHF (20.1% vs. 4.0%, p < 0.001), AKI (39.8% vs. 8.3%, p < 0.001), infection (46.3% vs. 24.4%, p = 0.001), and cardiac rehospitalisation (4.4% vs. 0.0%, p = 0.018) in the patients with NT-proBNP > 450 pg/ml. Here, NPPB is linked to infection.