This research proves the expression pattern of exosomal lncRNA NNT-AS1 in CAFs, ascertains how it acts on HIF-1α to influence glucose metabolism, proliferation, and metastasis of PDAC cells, and reveals how it regulates metabolic reprogramming, cell proliferation, and metastasis in pancreatic cancer cells. The gene discussed is HIF1A; the disease is pancreatic neoplasm.