Homologous to the E6-associated protein carboxyl terminus domain containing 3 (HECTD3) promoted the polyubiquitination of solute carrier family 7 member 11 (SLC7A11) to trigger the degradation of SLC7A11, thereby promoting ferroptosis of CRC (Huang et al. 2023a, b). The gene discussed is SLC7A11; the disease is colorectal carcinoma.