SNAI1 and cancer: Furthermore, the involvement of SNAIL in cancer progression is of paramount importance as it facilitates the process of epithelial–mesenchymal transition (EMT), while the degradation of SNAIL through ubiquitination by the HECT structural domain E3 ubiquitin ligase 1 (HECTD1) is responsible for mediating this phenomenon (Wang et al. 2020a, b).