Furthermore, c-Myc promotes the transcriptional regulation and expression of WD-repeat protein 43(WDR43), a mechanism that facilitates the binding of WDR43 to ribosomal protein L11 (RPL11) and enhances the ubiquitination of p53 by MDM2, which reduces the stability of p53 proteins and induces chemotherapy resistance in CRC cells (Di et al. 2023). This evidence concerns the gene MDM2 and colorectal carcinoma.