In addition, TRAF6, a RING-type E3 ubiquitin ligase that binds and promotes enhancer of zeste homolog 2(EZH2) degradation, is inhibited by TRIM25, thereby promoting the stabilization of EZH2 and the characteristic state of CRC stem cells, promoting the resistance of cancer tissues to L-OHP (Zhou et al.2021a, b). Here, EZH2 is linked to colorectal carcinoma.