Macrophage M2, a subtype of immunosuppressive myeloid cells had positive correlation with CSC (r = 0.41, p < 0.0001), while CD8+ T cells negatively associated with CSC (r = −0.27, p < 0.0001), indicating the potential interaction between CSC and Macrophage M2 to impede anti-tumor cells infiltration (Fig. 3g). The gene discussed is CD8A; the disease is neoplasm.