To further explore the effect of soluble ALDOA on glycolysis, we detected that the expression of downstream ALDOA genes, including TP1, ECON, and PKM2, were significantly reduced during glycolysis in IgG4-RD patients (Fig. 7K), which was also seen in Usp25 KO mice (Fig. S10G). Here, PKM is linked to immunoglobulin G4-related sclerosing disease.