Additionally, we found that the basal and maximal respiration rates of B cells from IgG4-RD patients were reduced compared to HCs B cells (Fig. 5B), while Usp25 KO B cells had only reduced maximal respiration rate (Fig. S9C), but both IgG4-RD patients B cells and Usp25 KO B cells had significantly reduced glycolytic capacity (Fig. 5C, S9D). This evidence concerns the gene USP25 and immunoglobulin G4-related sclerosing disease.