TNF and psoriasis: TNF-α inhibitors were the first biologics drugs approved for the treatment of psoriasis.12, 19 Meta-analysis shows that among this class infliximab has the highest efficacy, followed by certolizumab, adalimumab, and etanercept.18, 19 The FDA approved sequentially etanercept (2004), infliximab (2005), adalimumab (2008), golimumab (2017), and certolizumab (2018).