ESR1 and neoplasm: Our findings corroborate several studies showing that women with PrBC more often have aggressive tumours in terms of ER and PR negativity,7,10,11,13,17 HER2 positivity,7,15 larger tumour size,9,10,14,17 lymph nodal involvement,10,11,17,28 distant metastases,11 more advanced stage,7, 8, 9,13,17 higher-grade tumours,7,10,11,13 and of HER2-positive or TNBC subtypes.7