At pH 7.4, these NPs were negatively charged (−10.3 mV), which prevents the adsorption of albumin and favors circulation in the blood,[42] whereas at pH 6.0, they were positively charged (0.00705 mV), which facilitates uptake by tumor cells.[43] The encapsulation efficiency (EE%) values for AZD8055 and XL413 were 83.5% and 75.1%, respectively. Here, ALB is linked to neoplasm.