TARDBP and early-onset autosomal dominant Alzheimer disease: Moreover, established concepts such as resilience against Alzheimer disease pathology must be considered in the context of a wider array of neurodegenerative diseases, as this resilience may be related in part to a relative lack of comorbidities (i.e., resilience against Alzheimer disease pathology may be related to an individual’s resistance to developing comorbid TDP-43 or vascular pathology) [1, 45, 61, 63, 93, 95].