The presence of ADNC and increased numbers of neurodegenerative pathologies were inversely correlated with APOE ε2, while ADNC, LBD, and increased neurodegenerative pathologies were positively correlated with APOE ε4 (Fig. 5), suggesting that APOE status has minimal impact on non-ADNC neurodegenerative processes in isolation, but may play a role in the development of multiple concurrent proteinopathies [62, 95]. The gene discussed is APOE; the disease is proteostasis deficiencies.