We evaluate the correlation between pathologies including ADNC, primary age-related tauopathy (PART), LBD, LATE-NC, hippocampal sclerosis, frontotemporal lobar degeneration with TDP-43 (FTLD-TDP), amyotrophic lateral sclerosis(ALS)/motor neuron disease (MND), Pick disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and various forms of CVD (as well as additional covariates, including cerebral amyloid angiopathy (CAA), multiple system atrophy (MSA), chronic traumatic encephalopathy (CTE), and prion disease). The gene discussed is TARDBP; the disease is frontotemporal dementia.