Using GEDI (Geometrically Enhanced Differential Immunocapture; a microfluidic device in conjunction with DAPI, CD45, CK19, and Pdx-1 staining) [124], circulating pancreatic cells were detected in 33% of patients diagnosed as cancer-free; however, these patients had intraductal papillary mucinous neoplasm (IPMN), a type of cystic lesion [116] considered a precursor of PDAC [125]. This evidence concerns the gene PDX1 and pancreatic intraductal papillary-mucinous neoplasm.