CDH1 and breast carcinoma: Based on the above-mentioned studies on breast cancer, we can postulate that hybrid dormant HER2 + eDCCs are more sensitive to reactivation signals than the mesenchymal-like type and, therefore, are the first type of eDCCs to transition back to the epithelial phenotype (acquiring high E-cadherin levels), exit dormancy, start proliferating, and form metastases.