PDX1 and familial pancreatic carcinoma: In agreement, dissemination of pancreatic cancer cells from early lesions has been described in a Pdx1-Cre-dependent knock-in mouse model for KrasG12D with a conditional null allele of P53, in presence of a YFP as reporter (also known as KPYC model for KrasG12D; p53fl/+; RosaYFP; Pdx1-Cre) ([38] and see Table 1 in “Experimental animal models to study early metastatic dissemination” section for more details of the model).