Using previously validated CCC detection systems, including EPISPOTTM [132] (CK19 +in CD45-depleted cells) and CellSearch [133] (CK+after epithelial cell adhesion molecule (EpCAM) enrichment), positive events that met the criteria for “cancer cells” were detected in a study of 53 patients diagnosed with benign colon diseases (diverticulosis, benign polyps, and Crohn’s disease, among others). The gene discussed is EPCAM; the disease is Crohn disease.