In line with these results, Cui et al. recently showed that loss of MLL3, a histone methyltransferase, increases metastatic colonization and enriches metastasis with hybrid Vimentin+/E-cadherin + cells when compared to MLL3 wild-type mesenchymal (Vimentin+/E-cadherin-) breast cancer cells [137]. Here, CDH1 is linked to breast carcinoma.