TGF-β1is also produced and secreted by accumulating immune cells, such asmonocyte-derived M2-polarized macrophages that promote the angiogenicpotential of carcinoma cells in vitro, resultingin increased release of VEGF and bFGF from the tumor cells Therefore,the recruitment of tumor-associated macrophages (TAMs), characterizedas M2-like macrophages, is a mechanism linking and driving angiogenesisand inflammation because the same cytokines can activate their accumulationand be further secreted by them to the microenvironment exhibitingeffects on both processes.72,77. The gene discussed is FGF2; the disease is neoplasm.