Recent results further showed significant upregulation of GDNF in serum and liver tissues of patients with liver fibrosis, that was positively associated with HSC activation markers, such as α‐smooth muscle actin (α‐SMA), and a regulatory role of GDNF/activin receptor‐like kinase 5 (ALK5)/Smads in HSCs activation.23 The gene discussed is GDNF; the disease is Hepatic fibrosis.