In this study, HOXA11‐AS was used as the target in a combination of bioinformatics approaches, to explore the molecular mechanism of HOXA11‐AS and the promotion of EMTs in PCa at the cellular and global levels, respectively, to elucidate the prognostic and clinicopathological significance of lncRNA HOXA11‐AS expression in cancer patients and to identify new theoretical and therapeutic targets for PCa metastasis. The gene discussed is HOXA11; the disease is cancer.