CD274 and neoplasm: which also participates in the regulation of PD‐L1 expression.[14, 15, 16, 17, 18] The histone methyltransferase enhancer of zeste homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2), is involved in promoting tumor development, proliferation, invasion, metabolism, and antitumor immunity.[19, 20, 21, 22] Although EZH2 participates in regulating PD‐L1 expression,[15, 16] it is not clear whether EZH2 affects the modification of PD‐L1 protein levels.