CD8A and colorectal cancer: We also evaluated the immune infiltration scores in a human colorectal cancer scRNA‐seq dataset[26] through gene set variation analysis (GSVA) with two immune gene lists.[36, 37] The analysis showed that high USP22 expression was related to lower memory CD8+T‐cell scores (***p < 0.001, Wilcoxon) (Figure 7J), and high USP22 expression was linked to an increase in T‐cell co‐inhibitory molecule expression, a decrease in TIL infiltration, and a higher Treg ratio (***p < 0.001, Wilcoxon) (Figure 7K).