We did not observe any APOE2 carriers and thus cannot infer the effects of humanin P3S on APOE2, which is associated with greater longevity and has been reported to display less affinity to its receptors compared to APOE3 and APOE4, as well as less amyloidosis pathology across age (Suri et al., 2013). The gene discussed is MT-RNR2; the disease is amyloidosis.