Considering the critical role of the SETDB1 in contacting and methylating PLK3 and then contributing to drug-resistance and metastasis in LINC00115-driven BCSC, we assessed the effects of TTD-IN treatment combined with LINC00115 antisense oligonucleotides (ASO) on breast cancer metastasis. The gene discussed is SETDB1; the disease is breast carcinoma.