LBR and hereditary disease: Similar to B-type lamins, inner nuclear membrane proteins such as LBR, emerin, and various isoforms of lamina-associated polypeptides 1 (LAP1) and LAP2 have also been reported to bind lamins and tether repressive chromatin at the nuclear periphery [12, 18, 75], and their dysregulation has been linked to severe genetic disorders [13, 14, 76].