In a single-arm Phase II clinical trial (NCT03556345), which enrolled 125 patients with HER2-positive locally advanced or metastatic GC (including gastroesophageal junction adenocarcinoma) previously treated with second-line or higher regimens, the study reported an ORR of 24.8%, a PFS of 4.1 months, a median time to disease progression of 4.2 months, and an OS of 7.9 months. Here, ERBB2 is linked to gastric cancer.