The U.S. Food and Drug Administration (FDA) marked the initiation of cancer-targeted ADC therapy in 2000 by approving the ADC drug Mylotarg for treating patients with acute myeloid leukemia (AML) meeting specific criteria (i.e., first relapse, over 60 years old, CD33-positive, and unsuitable for cytotoxic chemotherapy) [4]. Here, CD33 is linked to acute myeloid leukemia.