A recent study revealed that 8‐O‐acetyl shanzhiside methylester, a quality control biomarker for L. rotata, showed neuroprotective effect on cognitive impairments induced by sleep deprivation as well as anxiety-like behaviors through modulating NRF2 and nuclear factor erythroid 2-related factor 2 (NRF2) pathways [21]. The gene discussed is NFE2L2; the disease is Anxiety.