The pooled analysis of genes that had significantly different expression levels between responders (either “elite” or all SD/PR/CR) and non-responders from this immune gene cluster revealed increases in genes that encode for proteins known to increase T and B cell trafficking to tumors (CCL19, CXCL9), migration (MACF1) and tumor cell killing (GZMB). The gene discussed is MACF1; the disease is neoplasm.