By comparison, a study in patients with HPV-unrelated head and neck squamous cell carcinomas described the high-dimensional multi-omics and spatial data analysis assessed on surgical specimens (n = 21) in patients treated in a neoadjuvant phase I/II trial of SBRT with single-dose anti-PD-L1 durvalumab [33]. Here, CD274 is linked to head and neck squamous cell carcinoma.