ANXA2 and renal cell carcinoma: ANXA2 expression was also upregulated in TNM stage IV RCC (stage IV vs stage I, P < 0.001; stage IV vs stage II, P < 0.05; stage IV vs stage III, P < 0.05; Fig. 1B), as well as ISUP grade 4 tumors (grade 4 vs grade 1, P < 0.01; grade 4 vs grade 2, P < 0.001; grade 4 vs grade 3, P < 0.001; Fig. 1C).