Wang et al. [45] performed an RCT with 76 children/adolescents with obesity, high ALT levels and steatosis on ultrasound that were randomized to a control group without any intervention (Group 1), to a group of children with hypocaloric diet and aerobic exercise (Group 2), or to a group receiving vitamin E supplement of 100 IU/day (Group 3). This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.