TAC1 and migraine disorder: Myofascial trigger points (MTP) can be classified into active and latent trigger points.61 Active trigger points cause constant pain, while latent trigger points only elicit pain when manually palpated.61 It has been hypothesised that sustained muscle contraction in MTP leads to hypoxia and ischemia, resulting in increased concentrations of inflammatory mediators, such as calcitonin gene-related peptide (CGRP) and substance P.58 It seems that MTP in the muscle of mastication is common in both conditions, myofascial TMD and migraine.