Thin primary melanomas (such as MM28, Breslow = 0.8 mm) (Fig. 7A) or thick primitive melanomas (such as MM25, Breslow = 16 mm) (Fig. 7B) displayed a proliferative/differentiated ZEB2+ MITF+ SOX10+ phenotype with no or low ZEB1, SOX9 and NGFR expression (Fig. 7A, B). Here, ZEB2 is linked to melanoma.