Thus, DKK4 expression in CRC cancer cells reduces the expression of β-catenin in stromal cells in cancer tissues, resulting in the transformation of fibroblasts to form stress fibre-containing fibroblasts and Vimentin+F-actin+MYH9+α-SMA+ myofibroblasts in cancer stromal tissues. This evidence concerns the gene ACTA1 and colorectal carcinoma.