Reduced expression of DKK4 was able to inhibit CRC metastasis by subcutaneous inoculation and intraperitoneal inoculation but not by intravenous or intrasplenic injection, suggesting that the function of DKK4 has no significant effects on the migration, the survival in the blood circulation, and distal colonization of CRC cells and might mainly display roles in the primary tumour tissues to promote CRC metastasis. Here, DKK4 is linked to colorectal carcinoma.