Moreover, inducing the formation of TLS, like by intratumoral injection of vital cytokines such as CXCL13 (Delvecchio et al. 2021), administration of engineered cells (GeurtsvanKessel et al. 2009) and tumor vaccines (Zhang et al. 2021), may provide a neoteric perspective for synergistic immunotherapeutic method. The gene discussed is CXCL13; the disease is neoplasm.