The fact that males were more affected than females seems to be in agreement with the liver phenotype and histological data where KO males exhibit an exacerbated inflammatory state based on the F4/80 marking (Fig. 2) and FGF21 hepatokine (Fig. 3j), increased ALT activity and no changes in circulating cortisol levels, as detailed above, which would point out to a somewhat more advanced stage of liver disease in KO males. This evidence concerns the gene FGF21 and liver disorder.