LRPPRC and obesity due to melanocortin 4 receptor deficiency: To study such cardiac abnormalities of a NAFLD in the absence of obesity and independently of any pre-existent metabolic disruptions and comorbidities, we took advantage of our hepatic Lrpprc knockout (KO) mouse model (H-LRPPRC) characterized by a mitochondrial dysfunction consequently to a defect in the assembly of respiratory chain complex IV13–15.